Synthesis of 7-substituted pyrazolo[1,5-a]pyrimidine-3-carboxamides as potential non benzodiazepine hypnotics
نویسندگان
چکیده
منابع مشابه
Residual Effects of Short Half-life Non-benzodiazepine Hypnotics
Background Since their introduction at the beginning of the 1990s the short half-life nonbenzodiazepine hypnotics, zolpidem and zopiclone, rapidly were among the most frequently prescribed hypnotics. Surveys showed that around 1996 the most frequently prescribed hypnotic in the US was zolpidem, while zolpidem and zopiclone were among the five most frequently used hypnotics in Europe [1, 2]. The...
متن کاملResidual effects of benzodiazepine and non-benzodiazepine hypnotics on diurnal attention in a reaction time task
xiety and sleep disorders. However, they have frequently negative residual effects on tasks requering spatial and visual abilities and sustained attention. Moreover, benzodiazepines may provoke an impairment of motor responses, also altering the capacity to estimate the time (Bensimon et al., 1990; Bocca et al, 1999; Myzuki et al., 1987; Sierra et al., 1993). Consequently, the level of attentio...
متن کاملSubstituted N-Phenylpyrazine-2-carboxamides: synthesis and antimycobacterial evaluation.
The condensation of chlorides of substituted pyrazinecarboxylic acids with ringsubstituted anilines yielded twelve substituted pyrazinecarboxylic acid amides. The synthetic approach, analytical, and lipophilicity data of the newly synthesized compounds are presented. Two antituberculosis assays were used. Firstly, the antimycobacterial activity against four different Mycobacterium strains in a ...
متن کاملSubstituted N-benzylpyrazine-2-carboxamides: synthesis and biological evaluation.
A series of twelve amides was synthesized via aminolysis of substituted pyrazinecarboxylic acid chlorides with substituted benzylamines. Compounds were characterized with analytical data and assayed in vitro for their antimycobacterial, antifungal, antibacterial and photosynthesis-inhibiting activity. 5-tert-Butyl-6-chloro-N-(4-methoxybenzyl)pyrazine-2-carboxamide (12) has shown the highest ant...
متن کاملParallel synthesis of 2-substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides.
A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides 10{1,2; 1-12} was prepared by a parallel solution-phase approach. The synthesis comprises a five-step transformation of itaconic acid (11) into 1-methyl and 1-phenyl substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxylic acids 17{1,2} followed by parallel amidation of 17{1,2} with a series of 12 aliphatic a...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2010
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0011.222